Abstract #1747

A Promising Procedure for the Staging of Liver Fibrosis Using Hepatocyte Fraction

Weibo Chen¹, Tian Qiu², Eunju Kim³, and YuXin Shi*²

¹Philips Healthcare, Shanghai, China, ²Shanghai Public Health Clinical Center Affiliated to Fudan University, Shanghai, China, ³Philips Healthcare, Seoul, Korea, Republic of

Liver biopsy is an invasive and painful procedure for staging liver fibrosis. This study aimed to evaluate a new procedure by injecting a hepatobiliary-specific contrast agent Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) and using a pharmacokinetic model to stage the liver fibrosis noninvasively. The hepatocyte fraction extracted from this new model decreased as the liver fibrosis stage increased, indicating that it might be a promising biomarker for the noninvasive staging of liver fibrosis.

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