Abstract #1748

Non-invasive assessment of portal hypertension using magnetic resonance elastography and ultrasound shear wave elastography of the liver and spleen.

Paul Kennedy^1,2, Octavia Bane^1,2, Stefanie Hectors^1,2, Scott Friedman³, Thomas Schiano³, Maria Isabel Fiel⁴, Swan Thung⁴, Aaron Fischman⁵, and Bachir Taouli^1,2

¹Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁴Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁵Department of Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States

The aim of this ongoing prospective study is to investigate the utility of both 2D and 3D MR elastography (MRE) and ultrasound shear wave elastography (SWE) for the assessment of portal hypertension in patients with chronic liver disease. Initial results indicate that 3D MRE measured spleen stiffness and the spleen to liver stiffness ratio measured with 3D MRE and SWE significantly correlate with hepatic venous pressure gradient measurement. This suggests that 3D MRE is sensitive to physiological changes associated with portal hypertension. Confirmation in a larger patient cohort may validate 3D MRE as a non-invasive surrogate for portal pressure measurement.

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