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Abstract #1753

Non-invasive assessment of hepatic fibrosis and inflammatory activity in patients with chronic hepatitis B:Comparison of multiple diffusion-weighted MR imaging models

Fang fang Fu1, Xiaodong Li1, Yan Bai1, Qiuyu Liu2, Da peng Shi1, Yusong Lin3, and Meiyun Wang1

1Department of Radiology, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, China, 2Department of Pathology, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University,Zhengzhou, 450003, China., Zhengzhou, China, 3Cooperative Innovation Center of Internet Healthcare & School of Software and Applied Technology, Zhengzhou University, Zhengzhou, 450001, China., Zhengzhou, China

In this study, we assessed the value of various diffusion parameters obtained from monoexponential, biexponential, and stretched-exponential DWI models in predicting the hepatic fibrosis (HF) stage and inflammatory activity grade in patients with chronic hepatitis B (CHB). We found that true diffusion coefficient (Dt) and distributed diffusion coefficient (DDC) are promising indicators and outperform the standard apparent diffusion coefficient (ADCst) for HF staging and inflammatory activity grading. We believe that biexponential and stretched-exponential model could be more helpful compared with monoexponential model in monitoring the progression of HF and inflammatory activity, guiding therapy, and assessing the effect of the treatment.

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