Abstract #1756

Temperature sensitivities of T1, fat fraction and water resonance frequency characterised in ex vivo human livers

Liam AJ Young¹, Carlo DL Ceresa², Ferenc E Mozes¹, Jane Ellis¹, Ladislav Valkovic^3,4, Constantin C Coussios⁵, Peter J Friend², and Christopher T Rodgers^1,6

¹Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom, ²Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ³University of Oxford, Oxford, United Kingdom, ⁴Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, ⁵Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, ⁶Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom

MR techniques enable viability assessment of ex vivo organs for transplantation and non-invasive post-mortem examinations. However, temperature variations in ex vivo tissue and cadavers can drastically alter MR measurements of T₁ and fat fraction, which risks masking underlying pathology if not considered carefully. Therefore, we investigated the changes observed in fat fraction and T₁ in ex vivo human livers during a period of cooling and re-warming. Obtaining multiple measurements at different temperatures enabled determination of temperature sensitivity independent of underlying pathology, which could be used to perform a “temperature correction” of ex vivo data allowing greater sensitivity to pathological changes.

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