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Abstract #1756

Temperature sensitivities of T1, fat fraction and water resonance frequency characterised in ex vivo human livers

Liam AJ Young1, Carlo DL Ceresa2, Ferenc E Mozes1, Jane Ellis1, Ladislav Valkovic3,4, Constantin C Coussios5, Peter J Friend2, and Christopher T Rodgers1,6

1Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom, 2Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, 3University of Oxford, Oxford, United Kingdom, 4Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, 5Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, 6Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom

MR techniques enable viability assessment of ex vivo organs for transplantation and non-invasive post-mortem examinations. However, temperature variations in ex vivo tissue and cadavers can drastically alter MR measurements of T1 and fat fraction, which risks masking underlying pathology if not considered carefully. Therefore, we investigated the changes observed in fat fraction and T1 in ex vivo human livers during a period of cooling and re-warming. Obtaining multiple measurements at different temperatures enabled determination of temperature sensitivity independent of underlying pathology, which could be used to perform a “temperature correction” of ex vivo data allowing greater sensitivity to pathological changes.

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