Abstract #1755

Quantitative DCE-MRI Analysis without an Arterial Input Function: A Comparison Study with Compartment Modeling in Liver Lesions

Ramin Jafari¹, Pascal Spincemaille², Martin R. Prince², Liangdong Zhou¹, and Yi Wang¹

¹Cornell University, New York, NY, United States, ²Weill Cornell Medicine, New York, NY, United States

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a noninvasive techniques to study dynamics of enhancement curves after administration of contrast agent. The traditional Kety’s based compartment modeling requires an arterial input function (AIF) to estimate perfusion parameters. Estimated perfusion parameters are highly dependent on the selected AIF including its magnitude and shape. We propose Quantitative transport mapping (QTM) which doesn’t require an AIF and incorporates both temporal and spatial dynamics of the contrast agent for similar analysis.

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