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Abstract #1764

MRI Relaxometry based Liver Iron Content Determination: Comparing Gradient-Echo R2* and Spin-Echo with respect to Age and Gender

Arthur Peter Wunderlich1,2, Valeria Mauro1, Meinrad Beer1, Stefan Andreas Schmidt1, and Holger Cario3

1Dept. for Diagnostic and Interventional Radiology, Ulm University, Medical Center, Ulm, Germany, 2Section for Experimental Radiology, Ulm University, Medical Center, Ulm, Germany, 3Clinic for Pediatric and Adolescent Medicine, Ulm University, Medical Center, Ulm, Germany

To address probable differences in signal characteristics between spin-echo (SE) and gradient-echo (GRE), 83 patients suspected for liver iron overload were investigated with 1.5 T MRI with the approved FerriscanĀ® method based on SE, and a prototype breathhold 3D GRE protocol employing parallel imaging with in-line R2* calculation. R2* values were correlated with reference LIC for all patients together and in subgroups according to age and gender. Highly significant differences (P=0.009) were found between males and females in the age range from 12 to 45 years, possibly reflecting different underlying iron storage mechanisms.

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