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Abstract #1765

Susceptibility-weighted imaging (SWI) compared to T2* mapping in the presence of hepatic steatosis and fibrosis

Verena Carola Obmann1, Nando Mertineit1, Annalisa Berzigotti2, Christina Marx1, Lukas Ebner1, Michael Ith1, Johannes Heverhagen1, Andreas Christe1, and Adrian Huber1

1Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern, Switzerland, 2Visceral Surgery and Medicine, Inselspital, Bern, Switzerland

We hypothesized, that susceptibility weighted imaging (SWI) and T2*-mapping are dependent on liver steatosis, which should be taken into account when using these parameters to grade liver fibrosis and cirrhosis. In this study 184 patients underwent multiparametric MRI at 3T including SWI, T1/T2* mapping as well as proton density fat fraction quantification and MR elastography as reference standard. SWI and T2* were both highly dependent on the degree of liver steatosis (p<0.001). However, SWI allowed a better differentiation between liver fibrosis grades (p <0.001) than T2*. Nevertheless, both parameters are useful predictors for liver fibrosis when using a multiparametric approach.

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