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Abstract #1767

Determining Liver Function: Comparison of Gadoxetate Pharmacokinetic Models Using Perfusion Imaging

Markus Karlsson1, Susmita Basak2, David Longbotham2, Steven Sourbron2, Gunnar Cedersund3, and Peter Lundberg1

1Department of Medical and Health Sciences, Linköping University, Linköping, Sweden, 2Imaging Biomarkers group, Department of Biomedical Imaging, Leeds University, Leeds, United Kingdom, 3Department of Biomedical Engineering, Linköping University, Linköping, Sweden

Hepatic uptake rate of Gadoxetate is a liver function biomarker. Different approaches for pharmacokinetic modelling exists, both with regards to model architecture and choice of input data, with both blood and spleen being used to estimate input‑function. We fitted three models to perfusion data, using both aorta and portal venous inputs, as well as splenic input. We showed that the hepatic uptake rate of Gadoxetate is robust, in that the uptake rate is not very dependent on how the liver perfusion is modelled. However, the choice of vascular or splenic input can affect the uptake rate.

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