Abstract #1796

Relationship between Brown Adipose Tissue and Intrahepatic Triglyceride in Children with Non-alcoholic Fatty Liver Disease

Steve Cheuk Ngai Hui^1,2, Dorothy Fung Ying Chan³, David Ka Wai Yeung^1,4, and Winnie Chiu Wing Chu¹

¹Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Sha Tin, Hong Kong, ²Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Department of Paediatrics, The Chinese University of Hong Kong, Sha Tin, Hong Kong, ⁴Department of Clinical Oncology, The Chinese University of Hong Kong, Sha Tin, Hong Kong

This study reported preliminary results for relationship between brown adipose tissue (BAT) and intrahepatic triglycerides (IHTG) in young subjects and tested whether non-alcoholic fatty liver disease (NAFLD) affected the association among liver fat accumulation and the activity and volume of BAT. Results showed that T2* in BAT was significantly lower in non-NAFLD group possibly due to higher blood flow and iron concentration which further implied the possibility of higher activation state of BAT in non-NAFLD. Correlation analysis also indicated NAFLD possibly changed the association between body weight and accumulation of IHTG as well as the volume and activity of BAT.

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