Abstract #1797

Pre-contrast T1 measurement in the liver and spleen for the non-invasive assessment of portal hypertension

Octavia Bane^1,2, Stefanie Hectors^1,2, Paul Kennedy^1,2, Scott Friedman³, Thomas Schiano³, Maria Isabel Fiel⁴, Swan Thung⁴, Aaron Fischman⁵, and Bachir Taouli^1,2

¹Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁴Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁵Department of Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States

The purpose of our prospective study was to assess the diagnostic value of liver and spleen T₁ for diagnosis of portal hypertension based on hepatic venous pressure gradient (HVPG) in patients with chronic liver disease. We found that mean and median liver T₁ were significantly elevated in patients with clinically significant portal hypertension versus those without clinically significant portal hypertension. We conclude that liver T₁ is potentially sensitive to parenchymal changes associated with portal hypertension, to be confirmed in a larger number of patients.

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