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Abstract #1798

Dynamic contrast enhanced MRI with clinical hepatospecific MRI contrast agents in pigs: initial experience

Jeremy M.L. Hix1, Christiane L Mallett1, Matt Latourette1, Kirk A Munoz2, and Erik Shapiro1,3

1Department of Radiology, Michigan State University, East Lansing, MI, United States, 2Department of Small Animal Clinical Sciences, Michigan State University, East Lansing, MI, United States, 3Institute of Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, United States

Pigs are a valuable translational biomedical tool for liver disease, and imaging can play an important role in early detection and disease characterization, but hepatic functional MRI has never been reported in pigs. Here we characterized baseline hepatic functional MRI in pigs, by performing DCE-MRI studies using two FDA-approved hepatospecific MRI contrast agents, and determined optimal animal protocols for acquiring robust data. Porcine liver has rapid accumulation of Gd-EOB-DTPA and Gd-BOPTA, following IV injection of equivalent human doses. Given the disparity in contrast agent uptake with humans for Gd-BOPTA, Gd-EOB-DTPA should be used in porcine models for biomedical imaging.

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