Abstract #1799

Quantitative 31P magnetic resonance spectroscopy detects insulin-mediated reduction of hepatic ATP content in type 2 diabetic patients

Jong-Hee Hwang^1,2, Frithjof Wickrath^1,2, Alessandra Bierwagen^1,2, Sofiya Gancheva ^1,2,3, Maria Apostolopoulou^1,2,3, Yuliya Kupriyanova ^1,2, Dominik Pesta^1,2, and Michael Roden^1,2,3

¹Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany, ²German Center for Diabetes Research (DZD e.V.), München-Neuherberg, Germany, ³Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany

Decreased insulin sensitivity precedes the onset of type 2 diabetes mellitus (T2DM). Hepatic energy metabolism is assumed to be impaired in T2DM with reduced insulin sensitivity. However, little is known about changes of ATP content in response to acutely elevated insulin. Therefore utilizing ³¹P MRS, we quantified ATP content before and after acute hyperinsulinemia. After a hyperinsulinemic clamp test, hepatic γ-ATP concentrations (ATP) were significantly reduced by 18% (p=0.008) in T2DM but not in controls. This study demonstrated that quantitative ³¹P MRS allows to monitor acute changes in hepatic ATP concentrations in vivo in various metabolic conditions.

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