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Abstract #1869

Pre-chemo MRI staging of axillary lymph node metastasis in breast cancer: validation with PET

Pauline Huang1, Renee Faith Cattell1, Julie Leong1, Meghan Italo1, Jason Ha1, Dinko Franceschi1, Jules Cohen1, Haifang Li1, Lea Baer1, Cliff Bernstein1, Roxanne Palermo1, and Timothy Duong1

1Stony Brook University, Stony Brook, NY, United States

This study evaluated the use of pre-chemo MRI of axillary lymph nodes (aLNs) to detect metastasis in breast cancer with PET and pathology as reference standards. PET versus pathology reports agreed 87% for presence of disease in the aLNs, while PET and MRI reports agreed 93%. We found good agreement between MRI and PET scores (Cohen’s Kappa 𝜅= 0.39, p=10-5). The MRI sensitivity, specificity, NPV and accuracy were 66.1%, 72.1%, 73.1% and 69.9%, respectively. Although improvement is needed, MRI staging of aLN is possible and practical. This approach may prove helpful in diagnosis and treatment planning of breast cancer patients.

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