Abstract #1879

Ventilation defects on hyperpolarized helium-3 MRI are predictive of 2-year exacerbation frequency in asthma

David Mummy¹, Katherine J Carey², Michael Evans³, Wei Zha², Ronald Sorkness^4,5,6, Mark Schiebler⁷, Loren Denlinger⁴, Nizar Jarjour⁴, and Sean Fain^1,2,7

¹Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ²Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ³Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, United States, ⁴Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁵Pharmacy, University of Wisconsin-Madison, Madison, WI, United States, ⁶Pediatrics, University of Wisconsin-Madison, Madison, WI, United States, ⁷Radiology, University of Wisconsin-Madison, Madison, WI, United States

Ventilation defects on hyperpolarized ³He MRI in asthma are predictive of exacerbation frequency in the two years following imaging. Incorporating VDP and exacerbation history into a single model allows for a decision-tree based approach to assessing propensity for asthma exacerbation.

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