Abstract #1880

Comparison of quantified pulmonary blood flow using phase-resolved functional lung (PREFUL) MRI and dynamic contrast enhanced MRI in COPD, CF and CTEPH patients

Lea Behrendt^1,2, Andreas Voskrebenzev^1,2, Filip Klimes^1,2, Marcel Gutberlet^1,2, Till Kaireit^1,2, Tawfik Moher Alsady^1,2, Frank Wacker^1,2, and Jens Vogel-Claussen^1,2

¹Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, ²Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany

Phase-resolved functional lung (PREFUL) MRI is a very promising method for contrast agent free pulmonary perfusion measurement in free breathing. Still a large-scale validation of quantified pulmonary blood flow (PBF_PREFUL) with the current gold standard PBF_DCE derived by dynamic contrast enhanced (DCE) MRI is missing. Therefore, 52 patients with COPD, CF and CTEPH were included in this study and the correlations for PBF_PREFUL and PBF_DCE were assessed. Except for CTEPH, strong and moderate correlations were found. Low or no correlation can be explained by respiratory motion (DCE) and perfusion delay (PREFUL).

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