Abstract #1881

Octafluorocyclobutane as a novel 19F MRI gas agent for significant lung image quality improvement

Yurii Shepelytskyi¹, Tao Li², Francis T Hane^2,3, Alanna Wade³, Vira Grynko¹, Camryn Newman⁴, and Mitchell S Albert^2,3,5

¹Chemistry and Materials Science Program, Lakehead University, Thunder Bay, ON, Canada, ²Thunder Bay Regional Health Research Institute, Thunder Bay, ON, Canada, ³Chemistry, Lakehead University, Thunder Bay, ON, Canada, ⁴Biology, Lakehead University, Thunder Bay, ON, Canada, ⁵Northern Ontario School of Medicine, Thunder Bay, ON, Canada

Two different MRI gas techniques are presently being employed for lung imaging: hyperpolarized noble gas MRI and fluorinated inert gas MRI. Perfluoropropane (PFP) is the most widely used ¹⁹F gas for imaging purposes. In this work, we demonstrate the feasibility of using an octafluorocyclobutane (OFCB) as a novel gas contrast agent for ¹⁹F lung MRI. Furthermore, the direct comparison between OFCB and PFP was performed In Vivo and In Vitro. OFCB, due to its chemical structure and relaxation properties, demonstrated a higher SNR. Therefore, usage of OFCB can significantly improve the image quality of ¹⁹F lung MRI.

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