Two different MRI gas techniques are presently being employed for lung imaging: hyperpolarized noble gas MRI and fluorinated inert gas MRI. Perfluoropropane (PFP) is the most widely used 19F gas for imaging purposes. In this work, we demonstrate the feasibility of using an octafluorocyclobutane (OFCB) as a novel gas contrast agent for 19F lung MRI. Furthermore, the direct comparison between OFCB and PFP was performed In Vivo and In Vitro. OFCB, due to its chemical structure and relaxation properties, demonstrated a higher SNR. Therefore, usage of OFCB can significantly improve the image quality of 19F lung MRI.