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Abstract #1881

Octafluorocyclobutane as a novel 19F MRI gas agent for significant lung image quality improvement

Yurii Shepelytskyi1, Tao Li2, Francis T Hane2,3, Alanna Wade3, Vira Grynko1, Camryn Newman4, and Mitchell S Albert2,3,5

1Chemistry and Materials Science Program, Lakehead University, Thunder Bay, ON, Canada, 2Thunder Bay Regional Health Research Institute, Thunder Bay, ON, Canada, 3Chemistry, Lakehead University, Thunder Bay, ON, Canada, 4Biology, Lakehead University, Thunder Bay, ON, Canada, 5Northern Ontario School of Medicine, Thunder Bay, ON, Canada

Two different MRI gas techniques are presently being employed for lung imaging: hyperpolarized noble gas MRI and fluorinated inert gas MRI. Perfluoropropane (PFP) is the most widely used 19F gas for imaging purposes. In this work, we demonstrate the feasibility of using an octafluorocyclobutane (OFCB) as a novel gas contrast agent for 19F lung MRI. Furthermore, the direct comparison between OFCB and PFP was performed In Vivo and In Vitro. OFCB, due to its chemical structure and relaxation properties, demonstrated a higher SNR. Therefore, usage of OFCB can significantly improve the image quality of 19F lung MRI.

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