Abstract #1882

Ventilation perfusion matching in patients with Cystic Fibrosis assessed via co-registered hyperpolarised gas and dynamic contrast enhanced lung MRI

Paul J.C. Hughes¹, Laurie Smith^1,2, Jody Bray¹, Oliver Rodgers¹, Martin Wildman³, Noreen West², Alexander Horsley⁴, Helen Marshall¹, and Jim Wild^1,5

¹POLARIS, Academic Unit of Radiology, Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, United Kingdom, ²Sheffield Children's Hospital, Sheffield Children's NHS Foundation Trust, Sheffield, United Kingdom, ³Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom, ⁴Respiratory Research Group, Division of Infection, Immunity & Respiratory Medicine, University of Manchester, Manchester, United Kingdom, ⁵Insigneo Institute for in silico Medicine, The University of Sheffield and Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom

Assessment of regional ventilation and perfusion is of clinical interest for better understanding of disease mechanisms and lung pathophysiology, as the primary function of the lung is gas exchange. This work aimed to assess ventilation and perfusion in patients with Cystic Fibrosis using co-registered hyperpolarised gas and dynamic contrast enhanced lung MRI.

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