Abstract #1894

USPIO-enhanced MRI for pre-operative lymph node staging after neoadjuvant chemoradiotherapy: feasibility and validation framework

Didi de Gouw¹, Bastiaan Klarenbeek¹, Marnix Maas², Rutger Stijns², Maroeska Rovers³, Cor Slagt⁴, Jörg Mühling⁴, John Hermans², Tom Scheenen², and Camiel Rosman¹

¹Surgery, Radboudumc, Nijmegen, Netherlands, ²radiology and nuclear medicine, Radboudumc, Nijmegen, Netherlands, ³health evidence and operating rooms, Radboudumc, Nijmegen, Netherlands, ⁴anesthesiology, pain and palliative medicine, Radboudumc, Nijmegen, Netherlands

Extensive lymph node dissections during esophagectomy may be omitted in patients with esophageal cancer without lymph node metastases, reducing associated morbidity. A promising technique to detect lymph node metastases is MRI with ultrasmall superparamagnetic iron oxide nanoparticles (USPIO, ferumoxtran-10). To validate USPIO-enhanced MRI in patients with esophageal cancer, a framework is designed to compare lymph nodes of the MRI scans with histopathology data on a node-to-node level.

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