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Abstract #1894

USPIO-enhanced MRI for pre-operative lymph node staging after neoadjuvant chemoradiotherapy: feasibility and validation framework

Didi de Gouw1, Bastiaan Klarenbeek1, Marnix Maas2, Rutger Stijns2, Maroeska Rovers3, Cor Slagt4, Jörg Mühling4, John Hermans2, Tom Scheenen2, and Camiel Rosman1

1Surgery, Radboudumc, Nijmegen, Netherlands, 2radiology and nuclear medicine, Radboudumc, Nijmegen, Netherlands, 3health evidence and operating rooms, Radboudumc, Nijmegen, Netherlands, 4anesthesiology, pain and palliative medicine, Radboudumc, Nijmegen, Netherlands

Extensive lymph node dissections during esophagectomy may be omitted in patients with esophageal cancer without lymph node metastases, reducing associated morbidity. A promising technique to detect lymph node metastases is MRI with ultrasmall superparamagnetic iron oxide nanoparticles (USPIO, ferumoxtran-10). To validate USPIO-enhanced MRI in patients with esophageal cancer, a framework is designed to compare lymph nodes of the MRI scans with histopathology data on a node-to-node level.

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