Proton MRI of lungs has challenges because of the available signal and high susceptibility of the air and tissue interface. Isoflurane is a commonly used fluorinated anesthetic with an excellent safety record in preclinical studies, which contains small amounts of the stable fluorine isotope 19F. This abstract demonstrates that Isoflurane can be used as both an anesthetic and as 19F contrast agent simultaneously. Inhaled isoflurane provides 19F signals in the gas and the dissolved phases which offers potentials for functional MR imaging of lungs.
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