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Abstract #1907

Effect of B0 shimming method and breath-holding position on the quantification of renal BOLD R2* in healthy volunteers

Charlotte E Buchanan1, Benjamin L Prestwich1, Eleanor F Cox1, and Susan T Francis1

1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom

Tissue hypoxia is thought to play a key role in the development and progression of kidney disease. Blood oxygenation level-dependent (BOLD) MRI based on the absolute transverse relaxation rate (R2*) is widely used to assess renal tissue oxygenation. This study shows that breath-hold location (inspiration/expiration) and B0 shimming method (default/volume) can influence the quantification of renal R2* mapping. By using associated B0 mapping data it is possible to determine outliers in R2* arising from significant left-right B0 gradients/B0 offsets/large B0 FWHM, thus reducing the variance in quantified renal R2* values across a subject group.

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