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Abstract #1908

Small field of view 2D spatially selective RF excitation diffusion tensor (DTI) imaging of the kidneys: initial experience in healthy controls and patients with Type 2 diabetes

Julia Williams1, Yuliya Perchyonok1,2, Leonid Churilov2,3, Emma Hornsey1, Lucy McKenna1, Niloufar Torkamani1,2, Daniel Staeb4, Julie Smith1, Elif Ekinci1,2, Artem Mikheev5, Henry Rusinek5, and Ruth P Lim1,2

1Austin Health, Heidelberg, Australia, 2The University Melbourne, Melbourne, Australia, 3The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, 4Siemens Healthcare Pty Ltd, Melbourne, Australia, 5New York University School of Medicine, New York, NY, United States

Fractional anisotropy (FA) and mean diffusivity (MD) derived from diffusion tensor imaging (DTI) are promising for assessing subclinical changes in diabetic kidney disease (DKD). However, renal echo planar DTI can be challenging due to susceptibility artefacts, which can be mitigated by a small field of view (FOV) 2D spatially selective RF excitation. We report initial experience at 3T in 9 controls and 4 diabetic patients, finding high inter-reader agreement for cortical and medullary FA and MD, and significantly lower medullary and cortical FA in patients compared to controls. Small FOV DTI is a feasible non-invasive method of DKD assessment/ monitoring.

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