Abstract #1911

Glomerular fibrosis in rat kidneys assessed with a clinical 3T MR scanner

Jeff L Zhang¹, Christopher C Conlin¹, Xiaowan Li¹, Bin Wang², Yufeng Huang², and Vivian S Lee³

¹Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States, ²Division of Nephrology, University of Utah, Salt Lake City, UT, United States, ³Verily Life Sciences, Cambridge, MA, United States

Glomerular fibrosis develops in multiple types of chronic kidney diseases. This study aims to explore the promising MRI methods for quantifying glomerular fibrosis, and to evaluate the feasibility of performing the measurements for rat kidneys using clinical MRI scanner. Four healthy and 4 fibrotic rats were included in the experiment. With fibrosis, significant changes were found in cortical and medullary T₁ and T₂. Measurement of T₂* suffered from susceptibility artifact. This study verified that clinical MRI scanners can be used to monitor the development of renal fibrosis in rat kidneys.

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