Abstract #1918

Dynamic changes in cyst growth rates in early autosomal dominant polycystic kidney disease

Harrison Kim¹, Allan Yu², Vicente E Torres³, Arlene B Chapman⁴, Frederic Rahbari-Oskoui⁵, Kyongtae Bae⁶, Peter C Harris³, William M Bennett⁷, Douglas P Landsittel⁶, and Michal Mrug¹

¹University of Alabama at Birmingham, Birmingham, AL, 35294, AL, United States, ²University of Kansas, Lawrence, KS, United States, ³Mayo clinic, Rochester, MN, United States, ⁴University of Chicago, Chicago, IL, United States, ⁵Emory University, Atlanta, GA, United States, ⁶University of Pittsburgh, Pittsburgh, PA, United States, ⁷Legacy Good Samaritan Hospital, Portland, OR, United States

The best method for the identification of high-risk patients with rapidly progressive autosomal dominant polycystic kidney disease (ADPKD) is based on height and age-adjusted total kidney volume (TKV). We sought to improve this assessment by exploring individual renal cyst growth rates over time. MRI data revealed that ADPKD cysts grow, remain stable or disappear. The individual cyst volume distribution over the first year (e.g., skewness or kurtosis) correlated strongly with TKV change over 3 years (better than TKV change over the first year). It remains to be determined whether these indices outperform TKV in the prediction of renal function outcomes.

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