IVIM DWI (intravoxel incoherent motion diffusion-weighted image) is a noninvasive imaging technology capable of simultaneously detecting diffusion and perfusion characteristics of renal tissue . This study investigates the feasibility of IVIM DWI in evaluating different degree of renal lesions. IVIM DWI was performed on sixteen rabbits with different degree of renal lesions, which were confirmed by the corresponding pathological results. A noticeable change of renal diffusion and perfusion can be clearly observed in different degrees of renal lesions. There exists significant difference in f values among four groups with different severity in renal lesions.