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Abstract #1926

Accumulation of saturated IMCL is associated with insulin resistance

David B Savage1, Laura Watson2, Katie Carr2, Claire Adams1, Soren Brage3, Krishna K Chatterjee1,2, Leanne Hodson4, Chris Boesch5, Graham J Kemp6, and Alison Sleigh1,2,7

1Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, United Kingdom, 2National Institute for Health Research/Wellcome Trust Clinical Research Facility, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, 3MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom, 4Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Oxford, United Kingdom, 5Department of Clinical Research and Radiology, AMSM, University Bern, Bern, Switzerland, 6Department of Musculoskeletal Biology, University of Liverpool, and MRC–Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA), Liverpool, United Kingdom, 7Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom

Use of a recently validated 1H MRS approach to determine both the intramyocellular lipid composition, and concentration independent of composition, within the soleus and tibialis anterior muscles of female individuals covering a wide range of insulin sensitivities, has revealed that accumulation of saturated intramyocellular lipid is more strongly associated with whole-body insulin resistance than concentration alone.

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