Abstract #1926

Accumulation of saturated IMCL is associated with insulin resistance

David B Savage¹, Laura Watson², Katie Carr², Claire Adams¹, Soren Brage³, Krishna K Chatterjee^1,2, Leanne Hodson⁴, Chris Boesch⁵, Graham J Kemp⁶, and Alison Sleigh^1,2,7

¹Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, United Kingdom, ²National Institute for Health Research/Wellcome Trust Clinical Research Facility, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, ³MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom, ⁴Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Oxford, United Kingdom, ⁵Department of Clinical Research and Radiology, AMSM, University Bern, Bern, Switzerland, ⁶Department of Musculoskeletal Biology, University of Liverpool, and MRC–Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA), Liverpool, United Kingdom, ⁷Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom

Use of a recently validated ¹H MRS approach to determine both the intramyocellular lipid composition, and concentration independent of composition, within the soleus and tibialis anterior muscles of female individuals covering a wide range of insulin sensitivities, has revealed that accumulation of saturated intramyocellular lipid is more strongly associated with whole-body insulin resistance than concentration alone.

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