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Abstract #1927

Spatially resolved measurement of lipid droplet size in white adipose tissue with high b-value stimulated echo-prepared diffusion-weighted 2D single shot TSE

Dominik Weidlich1, MingMing Wu1, Stefan Ruschke1, Daniela Franz1, Julius Honecker2, Oliver Gmach3, Thomas Skurk2, Hans Hauner2, Ulrich Kulozik3, and Dimitrios C. Karampinos1

1Department of Diagnostic and Interventional Radiology, Technical University Munich, Munich, Germany, 2Else Kröner Fresenius Center for Nutritional Medicine, Technical University Munich, Munich, Germany, 3Chair for Food and Bioprocess Engineering, Technical University Munich, Freising, Germany

Despite its strong relevance in metabolic dysfunction, non-invasive measurement of fat microstructure remains an unmet need. In white adipose tissue, enlarged adipocyte size is linked to the obese phenotype. DW-MRS has been previously applied to probe diffusion restriction effects of intramyocellular lipids or brown adipocytes using preclinical systems. However, probing diffusion restriction in large lipid droplets remains a major challenge and DW-MRS can only measure spatially averaged effects. This work proposes a method that probes lipid droplet sizes with high b-value stimulated-echo prepared DW 2D single shot TSE, validates the methods in water-fat phantoms and applies it in the gluteal fat depot in vivo.

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