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Abstract #1928

Metabolic Imaging of Brown Adipose Tissue in Aging Rodent Model

Rengaraj Anantharaj1, Jadegoud Yaligar1, Sanjay Kumar Verma1, Giang Le Thi Thu1, Kavita Kaur1, Venkatesh Gopalan1, Adaikalavan Ramasamy2, Karthik Mallilankaraman3, and S Sendhil Velan1

1Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Singapore, Singapore, 2Singapore Institute for Clinical Sciences, Singapore, Singapore, 3Department of Physiology, National University of Singaore, Singapore, Singapore

Loss of BAT function and activity is associated with aging. Understanding the metabolic and phenotypic changes in aging brown adipose tissue is important for healthy aging. In this study, we have characterized various brown adipose tissue depots including interscapular BAT(iBAT), cervical BAT(cBAT), and axillary BAT(aBAT) ) in aging rodent model. Fat content in all BAT depots increased with aging and reduced with β3 agonist treatment. The iBAT was more responsive to β3 intervention compared to other BAT depots. Functional genes PRDM16, PPARg, PGC1α were upregulated in BAT tissues of 3 months old animals with β3 agonist due to high metabolic activity and improved quality of BAT compared to older animals.

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