Abstract #1929

White fat browning in a murine model detected by Z-Spectrum Imaging

Alessandro M Scotti^1,2, Victoria Gil³, Weiguo Li^2,4, Chong Wee Liew³, and Kejia Cai^1,2

¹Radiology, University of Illinois at Chicago, Chicago, IL, United States, ²Bioengineering, University of Illinois at Chicago, Chicago, IL, United States, ³Biophysics and Biophysiology, University of Illinois at Chicago, Chicago, IL, United States, ⁴Research Resources Center, University of Illinois at Chicago, Chicago, IL, United States

"Browning" of visceral fat is of particular interest to human health due to its association to high risk of metabolic disease and its resistance to conventional browning stimuli. Developing a strategy to stimulate and monitor visceral fat browning could be extremely beneficial in combating epidemic metabolic diseases. Here we report the successful detection of white visceral fat browning in a treated transgenic mouse model by longitudinal Z-Spectrum Imaging. The fat-water fraction measured by ZSI and the fat depots volume were reduced over time compared to the control group. Being noninvasive and with no radiation, the protocol is suitable for longitudinal studies.

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