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Abstract #1930

On the Technical Challenges of Diffusion-Weighted MR Spectroscopy for Water ADC Quantification in Human Supraclavicular Fat

Mingming Wu1, Dominik Weidlich1, Stefan Ruschke1, Daniela Franz1, and Dimitrios Karampinos1

1Department of Diagnostic and Interventional Radiology, Technical University of Munich, Munich, Germany

The study of brown adipose tissue (BAT) has attracted many researchers in the context of human metabolism. In adult humans, BAT is mostly present in the supraclavicular fossa as a heterogeneous mixture of white and brown adipose tissue. DW MR is a powerful technique to detect microstructural differences which could potentially help to differentiate BAT from surrounding tissue. However, physiological motion in close proximity to the soft adipose tissue in the supraclavicular fossa could lead to signal cancelations and quantification errors. In this work we investigate the feasibility of human BAT DW-MRS for the ADC quantification of the water component in vivo.

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