There is a significant body of evidence suggesting that adipose hypoxia triggers systematic insulin resistance and type 2 diabetes. Non-invasive and longitudinal characterization of adipose tissue oxygenation during adipose tissue expansion would provide critical insight into the pathogenesis of type 2 diabetes. The major purpose of this study is to develop a non-invasive and quantitative measures of adipose oxygenation by MR. Our approach is based on exploiting the paramagnetic nature of O2 which can directly affect the lipid 1H longitudinal relaxation. We show that simple inversion recovery MR method can be potentially used for non-invasive quantification of adipose tissue hypoxia.
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