Abstract #1941

Proton density fat fraction mapping for tracking tissue changes under weight loss in cancer cachexia

Daniela Franz¹, Jan Syväri¹, Christoph Zöllner¹, Rickmer Braren¹, Ulrich Nitsche², Ernst J. Rummeny¹, and Dimitrios C. Karampinos¹

¹Department of Diagnostic and Interventional Radiology, Technische Universität München, München, Germany, ²Department of Surgery, Technische Universität München, München, Germany

Cancer cachexia, a multifactorial wasting syndrome, affects up to 50% of cancer patients and is a major cause of morbidity and mortality. Proton density fat fraction (PDFF) mapping based on a multi-echo gradient echo acquisition enables spatially-resolved fat quantification and can help characterize tissue changes during the course of cancer cachexia. This study investigates changes in volume and PDFF metrics of adipose tissue induced by weight loss in cancer cachexia.

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