The development of non-invasive imaging biomarkers for the detection and quantification of brown adipose tissue (BAT) remains an active research field thanks to the potential implications of BAT activation in treatment of metabolic dysfunction. BAT is known to be characterized by the presence of iron-rich mitochondria, increased oxygenation and denser vasculature compared to white adipose tissue. All above BAT characteristics would be expected to affect the T2 relaxation time of water within BAT. The present work aims to show the feasibility of measuring water-only T2 relaxation times using single-voxel MRS in the human supraclavicular fossa and to characterize the relationship of water T2 values to other metabolic and imaging parameters.
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