Abstract #1943

Changes of hepatocellular lipids and phosphorus metabolite content in diabetes patients over 5 years after diagnosis

Yuliya Kupriyanova^1,2, Oana-Patricia Zaharia^1,2, Volker Burkart^1,2, Karsten Müssig^1,2,3, Julia Szendroedi^1,2,3, Michael Roden^1,2,3, and Jong-Hee Hwang^1,2

¹Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research, Düsseldorf, Germany, ²German Center for Diabetes Research (DZD e.V.), München-Neuherberg, Germany, ³Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany

This study aimed at monitoring possible changes in hepatocellular lipids, γ-adenosine triphosphate and inorganic phosphate contents using 1H- and 31P-MRS in patients with type 1 or type 2 diabetes mellitus in the 1st year and at 5 years after diagnosis. Hepatocellular lipids content was higher at the 5-year follow-up in type 2, but not in type 1 diabetes patients. Diabetes patients generally exhibited decreases of phosphorus metabolites during the first 5 years of the disease.

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