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Abstract #1947

3D hepatocyte fraction index using 3D look locker

Yu Ueda1, Minori Onoda2, Naoki Ohno3, Makoto Obara1, Masami Yoneyama1, Yuta Akamine1, Satoshi Kobayashi3, Tosiaki Miyati3, and Marc Van Cauteren4

1Philips Japan, Tokyo, Japan, 2Division of Radiology, Kanazawa University Hospital, Kanazawa, Japan, 3Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan, 4Philips Healthcare, Tokyo, Japan

The Hepatocyte Fraction index (HeFra), which is based on a simple pharmacokinetic model, can quantitatively estimate the fraction of hepatocytes. It is calculated from R1 change between pre contrast and hepatobiliary phases. 2D look locker (LL) has been used to calculate T1 value in HeFra studies, but covers only a single slice in one breath hold. Clinically 3D scanning is preferable to get a wider coverage of the liver. Therefore, we optimized the imaging parameters of 3D LL. T1 value and HeFra using the optimized 3D LL were the same as those of 2D LL in subjects under T1 1400ms.

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