Abstract #1947

3D hepatocyte fraction index using 3D look locker

Yu Ueda¹, Minori Onoda², Naoki Ohno³, Makoto Obara¹, Masami Yoneyama¹, Yuta Akamine¹, Satoshi Kobayashi³, Tosiaki Miyati³, and Marc Van Cauteren⁴

¹Philips Japan, Tokyo, Japan, ²Division of Radiology, Kanazawa University Hospital, Kanazawa, Japan, ³Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan, ⁴Philips Healthcare, Tokyo, Japan

The Hepatocyte Fraction index (HeFra), which is based on a simple pharmacokinetic model, can quantitatively estimate the fraction of hepatocytes. It is calculated from R1 change between pre contrast and hepatobiliary phases. 2D look locker (LL) has been used to calculate T1 value in HeFra studies, but covers only a single slice in one breath hold. Clinically 3D scanning is preferable to get a wider coverage of the liver. Therefore, we optimized the imaging parameters of 3D LL. T1 value and HeFra using the optimized 3D LL were the same as those of 2D LL in subjects under T1 1400ms.

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