Fat-water MRI (FWMRI) provides a powerful means of exploring changes in the lipid content of brown adipose tissue (BAT) in response to cold exposure. Most previous FWMRI studies of changes in BAT's fat signal fraction (FSF) have done so only before and after cold exposure, however, and studies have used different FSF thresholds for defining BAT. Here, we show that in healthy young men, cold exposure elicits varied responses in BAT FSF, with areas of higher initial lipid content undergoing a net lipid depletion and areas of lower initial lipid content undergoing a net lipid accumulation.
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