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Abstract #1949

Simultaneous Assessment of Hyperpolarized [1-13C]Lactate and [13C]Bicarbonate with Fly-Back Echo Planar Imaging

Junjie Ma1, Edward P. Hackett1, Rolf F. Schulte2, and Jae Mo Park1,3,4

1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 2GE Healthcare, Munich, Germany, 3Department of Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 4Electrical Engineering, UT Dallas, Dallas, TX, United States

In this study, we designed a spectral-spatial radiofrequency pulse that excites hyperpolarized [13C]bicarbonate and [1-13C]lactate peaks simultaneously while suppressing [1-13C]alanine, [1-13C]pyruvate and [1-13C]pyruvate hydrate signal. In combination with multi-shot fly-back echo planar imaging readout, the excited bicarbonate and lactate images can be spatially separated with an appropriate echo-spacing. The proposed method was validated by a phantom study, and tested in vivo using healthy Wistar rats with hyperpolarized [1-13C]pyruvate.

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