Chronic
obstructive pulmonary disease (COPD) is often associated with pulmonary artery (PA)
hypertension (PH), however a mild to moderate PH is frequently not identified
on non-invasive testing in COPD patients. The novel non-invasive cardiovascular
magnetic resonance (CMR) derived parameter, velocity transfer function (VTF), has
been recently shown to correlate with invasive PA impedance. Here, we tested the
VTF to evaluate its association with clinical/pulmonary functional indices and
RV remodeling in patients in early COPD. We found that elevated VTF mean high
frequency modulus was associated with major clinical and functional criteria
indicating cardiovascular/respiratory dysfunction, which may link to PH.
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