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Abstract #2012

Early Detection of Myocardial Fibrosis by CMR Extracellular Volume Fraction Quantitation in a Hypertensive Swine Model

Baiyan Zhuang1, Chen Cui1, Arlene Sirajuddin2, Andrew Arai2, Shihua Zhao1, and Minjie Lu1

1Fuwai Hospital´╝î State Key Laboratory of Cardiovascular Disease, Beijing, China, 2National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, United States

At present, hypertensive left ventricular hypertrophy (LVH) is generally considered to be an adaptive hypertrophy of cardiomyocytes due to an increase in left ventricular afterload. However, recent studies have shown that myocardial interstitial fibrosis may play an important role in cardiac hypertrophy. This study aims to investigate the relationship between extracellular volume (ECV) fraction and left ventricular remodeling in hypertension by prospective randomized controlled swine model of hypertension, and explain its internal mechanism based on pathology.

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