Prior studies have shown that native T1 mapping at 3T provides an effective non-contrast approach for characterizing the presence and transmurality of chronic myocardial infarctions. The underlying mechanism is likely a combination of T1/T2 and magnetization transfer (MT) effects. The choice of flip angle is known to significantly affect the degree to which MOLLI-based T1 maps are confounded by MT and T2 effects. With the motivation to optimize the performance of MOLLI T1 mapping for detection of subendocardial infarcts, we hypothesized that increasing the flip angle beyond the conventionally-used 35° will provide a higher relative contrast and contrast-to-noise ratio between the infarcted myocardium and adjacent bloodpool.
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