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Abstract #2024

Association of Myocardial Tissue Characterization between Cardiovascular MR and 11C-acetate PET imaging

Shuai Liu1, Ximin Shi2, Xue Lin3, Li Huo2, Ligang Fang3, Fei Shang4, Xiaomeng Wu4, Shengji He4, Rui Guo1, Haiyan Ding1, Huimin Duan5, and Xihai Zhao1

1Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing, China, 2Department of Nuclear Medicine, Peking Union Medical College Hospital, Beijing, China, 3Department of Cardiology, Peking Union Medical College Hospital, Beijing, China, 4Department of Biomedical Engineering, Beijing Institute of Technology School of Life Science, Beijing, China, 5Department of Medical Engineering, First Affiliated Hospital of PLA General Hospital, Beijing, China

The metabolic alteration in myocardium always accompanied with the structural remodeling. Therefore, it is possible to bridge the imaging markers in CMR with those in 11C-acetate PET imaging. This study investigated the correlation of measurements of interventricular septum between CMR and 11C-acetate in healthy male adults. We found that there was a significant association between ECV measured by quantitative CMR and K1 measured by PET imaging. Our results may indicate a dynamic balance between myocardial blood flow and ECV physiologically. The clinical significance of this relationship needs to be further investigated in patients with cardiac diseases.

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