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Abstract #2023

Combined SAturation recovery and Variable flip Angle (SAVA) for free-breathing high-resolution three-dimensional cardiovascular magnetic resonance T1 mapping at 3T

Rui Guo1, zhensen chen1,2, Dongyue Si1, Daniel A. Herzka3,4, jianwen luo1, and Hanyan Ding1

1Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China, 2Vascular Imaging Laboratory, Department of Radiology, Vascular Imaging Laboratory, Seattle, WA, United States, 3National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States, 4Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, United States

Cardiac Magnetic Resonance T1 mapping enables quantitative characterization of myocardium, which appeals huge attention from clinic. In this work, we proposed a free-breathing high-resolution three-dimensional (3D) T1 mapping sequence. By using variable flip Angle technique for readouts and saturation-recovery preparation for T1 weightings, the proposed sequence is highly efficient in acquisition of all volumes, including the one at the equilibrium of the longitudinal magnetization. Whole-heart pre- and post-contrast homogeneous T1 maps at an imaging resolution 1.25×1.25×8 mm3 were successfully obtained within 10 minutes in healthy volunteers. After rigid registration, 3D Extracellular Volume maps were eventually achieved.

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