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Abstract #2041

In Vivo Potassium MRI of the Human Heart at 7.0 Tesla

Daniel Wenz1, Armin Michael Nagel2,3,4, Andre Kuehne5, and Thoralf Niendorf1,5

1Max Delbrueck Center for Molecular Medicine, Berlin, Germany, 2Institute of Radiology, University Hospital Erlangen, Erlangen, Germany, 3Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 4Institute of Medical Physics, University of Erlangen, Erlangen, Germany, 5MRI.TOOLS GmbH, Berlin, Germany

Potassium ions (K+) play a critical role in cardiac electrophysiology; changes in their concentration might reflect ongoing pathophysiological processes related to cardiovascular diseases. In vivo potassium (39K) MRI, due to its extremely low sensitivity remains a major challenge. Here we investigated, for the first time, the feasibility of in vivo 39K MRI of human heart in a healthy subject. To achieve this goal, we developed a custom-built 39K/1H RF coil, which is tailored for 39K MRI of human heart at 7.0 Tesla. This approach facilitated 39K MRI of human heart with an isotropic spatial resolution of 14.5 mm3 within a total scan time of 30 minutes.

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