Abstract #2042

Hyperpolarized Magnetic Resonance Reveals Cardiac and Hepatic Metabolic Dysfunction in the ZDF Model of Type 2 Diabetes

Jack J. Miller^1,2,3, Kerstin N Timm¹, Vicky Ball¹, Cher-Rin Chong¹, Justin Y C Lau^1,3, Jürgen E Schneider⁴, Günaj Rakipovski⁵, Birgitte Andersen⁵, and Damian Tyler^1,3

¹Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom, ²Department of Physics, University of Oxford, Oxford, United Kingdom, ³Oxford Centre for Clinical Cardiac Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom, ⁴Cardio Metabolic Research, University of Leeds, Leeds, United Kingdom, ⁵Novo Nordisk, Måløv, Denmark

The Zucker Diabetic Fatty (ZDF) rat is a well-known hyperinsulinaemic and hyperlipidaemic model of severe uncompensated Type 2 diabetes (T2DM) that displays systolic cardiac dysfunction late in life at the 40 week timepoint. Hyperpolarized Magnetic Resonance (MR) is a new medical imaging technique that can provide a novel way to probe metabolism in vivo and has been widely used to demonstrate physiological and pathological changes in pyruvate metabolism in the rodent heart. This work presents a magnetic resonance characterisation of the ZDF rat with hyperpolarized MR that detects metabolic alterations prior to the development of cardiac dysfunction.

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