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Abstract #2083

Identification of Carotid Non-Hemorrhagic Lipid-Rich Necrotic Core by Magnetization-Prepared Rapid Acquisition Gradient-Echo Imaging: Validation by Contrast-Enhanced T1W Imaging

Xihai Zhao1, Huiyu Qiao1, Hualu Han1, Dongxiang Xu2, Gaifen Liu3,4, and Chun Yuan2

1Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing, China, 2Department of Radiology, University of Washington, Seattle, WA, United States, 3Beijing Tiantan Hospital, Capital Medical University, Beijing, China, 4China National Clinical Research Center for Neurological Diseases, Beijing, China

Lipid-rich necrotic core (LRNC) plays a key role in the vulnerability of atherosclerotic plaques and is associated with ischemic cerebrovascular events. Previously, LRNC was identified using contrast-enhanced T1W (CE-T1W) imaging which needs administration of contrast agent. This study determined the capability of MP-RAGE imaging in identification of non-hemorrhagic LRNC (NH-LRNC) validated by CE-T1W. We found that moderate to good agreements between MP-RAGE and CE-T1W imaging in identification and quantification of NH-LRNC. MP-RAGE showed smaller bias in measuring NH-LRNC than T2W imaging. Our results suggest that MP-RAGE might be a better non-CE imaging technique for assessing NH-LRNC in carotid arteries.

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