Lipid-rich necrotic core (LRNC) plays a key role in the vulnerability of atherosclerotic plaques and is associated with ischemic cerebrovascular events. Previously, LRNC was identified using contrast-enhanced T1W (CE-T1W) imaging which needs administration of contrast agent. This study determined the capability of MP-RAGE imaging in identification of non-hemorrhagic LRNC (NH-LRNC) validated by CE-T1W. We found that moderate to good agreements between MP-RAGE and CE-T1W imaging in identification and quantification of NH-LRNC. MP-RAGE showed smaller bias in measuring NH-LRNC than T2W imaging. Our results suggest that MP-RAGE might be a better non-CE imaging technique for assessing NH-LRNC in carotid arteries.
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