Abstract #2084

Identification of Intrapalque Hemorrhage in Carotid Artery by Simultaneous Non-contrast Angiography and intraPlaque hemorrhage (SNAP) Imaging: Validation by Histology

Dongye Li^1,2, Huiyu Qiao¹, Yongjun Han¹, Hualu Han¹, Dandan Yang^1,2, Jingli Cao^3,4, Huimin Xu⁵, Tao Wang⁶, and Xihai Zhao¹

¹Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University of Medicine, Beijing, China, ²Center for Brain Disorders Research, Capital Medical University and Beijing Institute of Brain Disorders, Beijing, China, ³Beijing Tiantan Hospital, Capital Medical University, Beijing, China, ⁴China National Clinical Research Center for Neurological Diseases, Beijing, China, ⁵Department of Radiology, Peking University Third Hospital, Beijing, China, ⁶Department of Neurosurgery, Peking University Third Hospital, Beijing, China

It is important to accurately characterize carotid intraplaque hemorrhage (IPH) due to its strong association with plaque progression and ischemic stroke. Previous study proved that MP-RAGE is the best T1-weighted sequence in detecting carotid IPH. Most recently, investigators found that SNAP imaging can detect more IPHs compared with MP-RAGE. This study sought to investigate the performance of SNAP imaging in evaluating carotid IPH validated by histology. We found that SNAP sequence showed better agreement with histology compared with MP-RAGE in assessing IPH, suggesting that SNAP imaging might be a more sensitive and accurate imaging approach in characterizing carotid IPH.

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