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Abstract #2092

Evaluation of the endothelial (dys)function in a rabbit model of atherosclerosis by DCE-MRI and pharmacokinetic modelling

Peter Opriessnig1, Gunter Almer2, Claudia Cabella3, Stefan Ropele1, Seth Hallstroem4, and Gerd Hoerl4

1Division of General Neurology, Medical University of Graz, Graz, Austria, 2Clinical Institute for Medical and Chemical Laboratory Diagnosis, Medical University of Graz, Graz, Austria, 3Bracco Imaging SpA, Bracco Research Centre, Colleretto Giacosa, Italy, 4Department of Physiological Chemistry, Medical University of Graz, Graz, Austria

Endothelial dysfunction as a consequence of cardiovascular risk factors and increased endothelial permeability are involved in remodeling processes of the arterial wall and progression of AS early on. DCE-MRI in combination with pharmacokinetic modelling and a special nitric oxide donor compound together with dynamic vasomotor patterns could provide novel information related to changes of the endothelial function during the progression and pathogenesis of atherosclerosis and may contribute to a better mechanistic understanding of AS pathophysiology. In this work, we demonstrate the feasibility to investigate endothelial (dys)function and NO induced vasomotor function of the abdominal aorta in AS induced rabbits simultaneously.

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