Endothelial dysfunction as a consequence of cardiovascular risk factors and increased endothelial permeability are involved in remodeling processes of the arterial wall and progression of AS early on. DCE-MRI in combination with pharmacokinetic modelling and a special nitric oxide donor compound together with dynamic vasomotor patterns could provide novel information related to changes of the endothelial function during the progression and pathogenesis of atherosclerosis and may contribute to a better mechanistic understanding of AS pathophysiology. In this work, we demonstrate the feasibility to investigate endothelial (dys)function and NO induced vasomotor function of the abdominal aorta in AS induced rabbits simultaneously.
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