The purpose of the study was to assess the accuracy of left ventricular (LV) volumes and mass with innovative single breath-hold compression sensing (CS) cine CMR. 154 patients were enrolled for two techniques CMR cine. Two radiologists evaluated the image quality. LV volumes and mass were quantificationally analyzed. The image quality score of CS cine was slightly worse (4.7 ± 0.5 vs. 4.2 ± 0.7, Z = -5.934, p < 0.0001). All LV volumes and mass with two techniques were no significant differences (p > 0.05). CS cine CMR may replace the multiple breath-holds cine CMR.