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Abstract #2130

Left-atrial global longitudinal strain as an imaging biomarker of cardiac amyloidosis

Jadranka Stojanovska1, Behnaz Khazai1, Mason Runge1, Maryam Ghadimi1, Anil Attili1, Thomas Chenevert1, and El-Sayed H Ibrahim2

1University of Michigan, Ann Arbor, MI, United States, 2Medical College of Wisconsin, Milwaukee, WI, United States

Cardiac amyloidosis (CA) is a clinical disorder that could result in early death. MRI is a valuable modality for diagnosis of CA, where late-gadolinium enhancement is typically used for assessing adverse outcomes. However, in the era of unknown long-term effects of the gadolinium, there is a need to investigate alternative imaging biomarkers associated with CA, which is the primary aim of this study. The secondary aim is to evaluate the association between MRI variables and mortality in CA. The results demonstrated that depressed left-atrial global longitudinal strain is significantly associated with biopsy-proven CA, independent of other MRI and clinical measures.

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