Meeting Banner
Abstract #2156

Assessing the effects of substrate modulation on cardiac function and metabolism in the rodent heart with CINE MRI and hyperpolarized [1-13C]pyruvate

Kerstin N Timm1, William D Watson2, Vicky Ball1, Oliver J Rider2, and Damian J Tyler1,2

1Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, United Kingdom, 2John Radcliffe Hospital, Oxford Centre for Magnetic Resonance, Oxford, United Kingdom

Heart failure is associated with reduced cardiac energetics and this has been linked to impaired substrate utilization. We have assessed in rats how cardiac function and pyruvate dehydrogenase (PDH) flux change upon substrate manipulation, by varying plasma non-esterified fatty acid (NEFA) levels with acipimox injections in both fed and fasted rats. We found that NEFA depletion in fasted rats led to cardiac systolic dysfunction which may be explained by an insufficient compensatory increase in PDH flux boosting glucose oxidation. This model of substrate-manipulation heart failure could be used to assess potential heart-failure drugs in the future.

This abstract and the presentation materials are available to members only; a login is required.

Join Here