Subtle changes in strains and mechanical proprieties of the myocardial tissue were assessed in childhood acute lymphoblastic leukemia survivors using the optical flow and virtual field methods on CMR images. Significant changes between risk groups were observed on the strain in the 2 chambers view only. However, significant changes between risk groups were observed on the stresses, shear and Young’s moduli in all views. The dynamic elastic and shear moduli obtained along the cardiac cycle might be indicators of doxorubicin induced cardiotoxicity.
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